Table 4.
The association between lymph node stage and distant metastasis in thyroid cancer (SEER database years of 2010-2015).
| Group | Metastatic site rate | Unadjusted | Adjusteda | ||||
|---|---|---|---|---|---|---|---|
| n/N (%) | OR (95%CI) | P | OR (95%CI) | P | |||
| TC | |||||||
| Bone alone | 271/1,407 (19.3) | ||||||
| N0 | 151/584 (25.9) | Ref. | |||||
| NX | 39/178 (21.9) | 0.89 (0.63-1.25) | 0.491 | 0.77 (0.42-1.21) | 0.210 | ||
| N1 | 81/910 (8.9) | 0.46 (0.37-0.57) | <0.001 | 0.44 (0.34-0.57) | <0.001 | ||
| Lung alone | 720/1,407 (51.2) | ||||||
| N0 | 219/584 (37.5) | Ref. | |||||
| NX | 64/178 (36.0) | 1.01 (0.72-1.41) | 0.979 | 1.53 (0.89-2.65) | 0.126 | ||
| N1 | 437/910 (48.0) | 1.63 (1.31-2.01) | <0.001 | 1.99 (1.55-2.55) | <0.001 | ||
| PTC | |||||||
| Bone alone | 117/613 (19.1) | ||||||
| N0 | 63/258 (24.4) | Ref. | |||||
| NX | 10/53 (18.7) | 0.72 (0.38-1.38) | 0.322 | 0.56 (0.17-1.79) | 0.326 | ||
| N1 | 44/480 (9.2) | 0.41 (0.29-0.58) | <0.001 | 0.42 (0.29-0.62) | <0.001 | ||
| Lung alone | 379/613 (61.8) | ||||||
| N0 | 99/258 (38.4) | Ref. | |||||
| NX | 21/53 (39.6) | 1.12 (0.62-2.02) | 0.712 | 1.15 (0.41-3.21) | 0.793 | ||
| N1 | 259/480 (54.0) | 1.70 (1.25-2.32) | 0.001 | 2.22 (1.56-3.16) | <0.001 | ||
TC, thyroid cancer; PTC, papillary thyroid cancer; OR, odd ratio; CI, confidence interval.
a
Adjusted for age, race, gender, and tumor size.