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. 2020 Feb 27;11:110. doi: 10.3389/fgene.2020.00110

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Copyright © 2020 Mens, Maas, Klap, Weverling, Klatser, Brakenhoff, van Meurs, Uitterlinden, Ikram, Kavousi and Ghanbari

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regional plots showing the association of four top miRNA-SNPs with cardiometabolic traits. The most significant SNP in the region, according to P-value, is represented by a purple diamond, and the degree of linkage disequilibrium of other SNPs in the region to the lead SNP is representative by the color scale shown in the legend. Genes are illustrated below. The associated miRNA is illustrated with a red box. (A) Regional plot showing the association of rs7117842 located ~512kb upstream of miR-100-5p/125b-5p with TC, LDL and HDL on the Chr11q24.1 locus. (B) Regional plot showing the association of rs1997243 located ~21kb upstream of the primary transcript of miR-339-3p with TC and HDL on the Chr7p22.3 locus. (C) Regional plot showing the association of rs7607369 located ~11.7kb upstream of the primary transcript of miR-26b-5p with BMI and TG on the Chr2q35 locus. (D) Regional plot showing the association of rs472551 located ~2kb upstream of the primary transcript of miR-148a with LDL, TG, and TC on the Chr7p15.2 locus.