Table 1.
Description of genome-wide association studies (GWAS) of cardiometabolic traits and associated miRNA single-nucleotide polymorphisms (SNPs).
| Phenotype | Consortium | SNPs in +/-2kb miR* | SNPs in miR-seq* | SNPs in miR-QTL* | Associated miR loci† |
|---|---|---|---|---|---|
| Anthropometric traits | |||||
| Body-mass index | GIANT (Locke et al., 2015) | 9 | 0 | 9 | 7 |
| Waist to hip ratio | GIANT (Shungin et al., 2015) | 2 | 1 | 1 | 4 |
| Waist circumference | GIANT (Shungin et al., 2015) | 10 | 0 | 1 | 8 |
| Glycemic traits | |||||
| Glucose fasting | MAGIC (Manning et al., 2012) | 3 | 0 | 1 | 4 |
| Glucose after 2h | MAGIC (Saxena et al., 2010) | 0 | 0 | 0 | 0 |
| Insulin fasting | MAGIC (Manning et al., 2012) | 1 | 0 | 2 | 2 |
| Proinsulin | MAGIC(Strawbridge et al., 2011) | 3 | 0 | 4 | 3 |
| HbA1c | MAGIC (Wheeler et al., 2017) | 1 | 0 | 15 | 4 |
| HOMA-IR | MAGIC (Dupuis et al., 2010) | 0 | 0 | 0 | 0 |
| HOMA-β | MAGIC (Dupuis et al., 2010) | 0 | 0 | 0 | 0 |
| Type 2 diabetes | DIAGRAM (Scott et al., 2017) | 12 | 0 | 1 | 8 |
| Lipid traits | |||||
| LDL | GLGC (Willer et al., 2013) | 22 | 1 | 20 | 11 |
| HDL | GLGC (Willer et al., 2013) | 12 | 1 | 23 | 9 |
| Total cholesterol | GLGC (Willer et al., 2013) | 26 | 1 | 40 | 13 |
| Triglyceride | GLGC (Willer et al., 2013) | 8 | 1 | 27 | 7 |
| Cardiovascular traits | |||||
| CAD | CARDIoGRM plusC4D (Nikpay et al., 2015) |
10 | 0 | 2 | 4 |
| DBP | ICBP (International Consortium for Blood Pressure Genome-Wide Association et al., 2011) | 3 | 0 | – | 2 |
| SBP | ICBP (International Consortium for Blood Pressure Genome-Wide Association et al., 2011) | 2 | 0 | – | 2 |
Shown are SNPs located within +/-2kb of primary miRNA transcripts, pre- and mature miRNA sequences, miRNA-eQTL SNPs.
*Number of SNPs that passed the significance threshold (p-value < 2.12x10-5 for SNPs imputed with HapMap and p-value < 5.78x10-6 for SNPs imputed with 1000G).
†Number of independent loci.