Table 2.
The top 20 miRNAs with single-nucleotide polymorphisms (SNPs) in related regions association with cardiometabolic traits.
| miRNA | SNPID | Chr. | Position | Alleles (A/R) | Annotated gene | Genomic location miRNA |
Associated trait | β-coefficient | P value |
|---|---|---|---|---|---|---|---|---|---|
| miR-6886† | rs17248720 | 19 | 11198187 | C/T | LDLR | Intronic | LDL | 0.226 | 2.40x10-148 |
| miR-6863† | rs13306673 | 16 | 56900931 | C/T | SLC12A3 | Intronic | HDL | 0.098 | 2.76x10-48 |
| miR-4263† | rs2305929 | 2 | 28113911 | G/A | BRE | Intronic | TG | 0.064 | 1.13x10-44 |
| miR-6773† | rs8057119 | 16 | 68268836 | T/C | ESRP2 | Intronic | HDL | 0.072 | 5.21x10-40 |
| miR-611† | rs174538 | 11 | 61560081 | G/A | THEM258 | Exonic | LDL | 0.050 | 1.07x10-34 |
| miR-1908-5p‡ | rs174548 | 11 | 61571348 | C/G | FADS1 | Exonic | LDL | 0.047 | 2.29x10-31 |
| miR-10b-5p/126-5p‡ | rs532436 | 9 | 136149830 | A/G | ABO | Exonic/Intronic | LDL | 0.079 | 4.02x10-30 |
| miR-4721† | rs4788099 | 16 | 28763228 | G/A | TUMF | Exonic | BMI | 0.031 | 1.09x10-24 |
| miR-4531† | rs6509170 | 19 | 45159636 | C/A | LOC107985305 | Intronic | LDL | 0.127 | 1.54x10-22 |
| miR-199a-1† | rs11085748 | 19 | 10927540 | T/C | DNM2 | Intronic | LDL | 0.055 | 1.46x10-19 |
| miR-4999† | rs7254882 | 19 | 8359822 | C/T | MIR4999 | Intergenic | HDL | 0.033 | 6.66x10-18 |
| miR-4639† | rs3757354 | 6 | 16127407 | C/T | MYLIP | Intronic | LDL | 0.038 | 2.09x10-17 |
| miR-640† | rs1000237 | 19 | 19518316 | T/A | GATAD2A | Intronic | TG | 0.033 | 1.61x10-16 |
| miR-3161† | rs79837139 | 11 | 48000780 | C/T | PTPRJ | Intronic | HDL | 0.062 | 2.99x10-16 |
| miR-100-5p/125b-5p‡ | rs7117842 | 11 | 122663796 | C/T | UBASH3B | Intergenic/Intergenic | TC | 0.029 | 2.48x10-15 |
| miR-148a† | rs4722551 | 7 | 25991826 | C/T | MIR148A | Intergenic | LDL | 0.039 | 3.95x10-14 |
| miR-139† | rs11605042 | 11 | 72700619 | A/G | ARAP1 | Intronic | Pro-Ins | -0.053 | 5.24x10-13 |
| miR-3941† | rs71486610 | 10 | 124134803 | C/G | PLEKHA1 | Intronic | T2D | -0.081 | 3.30x10-11 |
| miR-6745† | rs901750 | 11 | 47209472 | A/G | PACSIN3 | Intronic | HDL | 0.024 | 3.95x10-11 |
| miR-196a-2-3p* | rs11614913 | 12 | 53991815 | C/T | MIR196A2 | Intergenic | WHR | 0.029 | 6.90x10-11 |
*SNP located in pre- and mature miRNA sequence.
†SNP located within +/- 2kb of primary miRNA transcript.
‡miR-eQTL SNP.