Table 3.
Identified me-QTLs with cardiometabolic-associated CpGs.
| miRNA | SNPID | CpG | Cis†/Trans | miR-eQTL SNP* | SNP associated with cardiometabolic trait |
CpG associated with cardiometabolic trait |
|---|---|---|---|---|---|---|
| miR-611 | rs174538 | cg16150798 | Cis | – | FG, LDL, HDL, TG, TC | WC |
| miR-588 | rs9388486 | cg20229609 | Cis | – | T2D | SBP, DBP |
| miR-1908-5p | rs174548 | cg03921599 | Cis | √ | FG, HbA1c, LDL, HDL, TG, TC | LDL, TC |
| miR-199a-1 | rs3786719 | cg02907064 | Cis | – | LDL, TC | LDL |
| miR-6745 | rs901750 | cg00724111 | Cis | – | HDL | FI, SBP, DBP |
| miR-8073 | rs3809346 | cg22382805 | Cis | – | CAD | FI |
| miR-653, miR-489 | rs2528521 | cg06934092 | Cis | – | BMI | FG, FI, TC |
| miR-8073 | rs3809346 | cg19700260 | Cis | – | CAD | DBP |
Shown are 7 me-QTLs associated with methylation levels of 8 cardiometabolic-associated CpG sites.
*miR-eQTL SNP is associated to change the expression of miRNA level.
†SNP and CpG are located not further away than 250kb.