Table 5.
Cardiometabolic-associated miRNAs after integrative multi-omics data and in silico prioritization analysis.
| miRNA | Associated traits |
SNPID | P value | Proxy SNPs (Non-syn.) | GWAS | miRNA CpG |
P value | Associated trait | miR-eQTM | Associated trait | miRNA Exp. | Associated trait |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| miR-10b-5p* | LDL†, TC, CAD, T2D | rs532436(‡) | 4.02x10-30 | 9 (0) | √ | cg25820279 | 4.37x10-02 | TC | – | – | 3.30x10-11 | TC |
| miR-148a-3p* | LDL†, TC, TG | rs4722551 | 3.95x10-14 | 1 (0) | √ | cg18188200 | 1.94x10-03 | TC | – | – | 8.01x10-06 | TC |
| miR-125b-5p* | TC†, LDL, HDL | rs7117842(‡) | 2.48x10-15 | 52 (0) | √ | cg06749053 | 2.39x10-02 | LDL | cg26363555 | HDL | 2.43x10-03 | TC |
| miR-100-5p* | TC†, LDL, HDL | rs7117842(‡) | 2.48x10-15 | 52 (0) | √ | cg14724899 | 4.02x10-02 | HDL | – | – | 3.15x10-03 | TC |
| miR-6886-3p | LDL†, TC, CAD | rs17248720 | 2.40x10-148 | 49 (0) | – | cg19751789 | 8.03x10-04 | TC | – | – | 9.49x10-03 | TC |
*MiRNAs which were associated with cardiometabolic traits using multi-omics approach and were according to the prioritization analysis more likely to be involved in the development of cardiometabolic traits. †Trait to which the SNP is associated. ‡miR-eQTL SNP.
Shown here are 5 miRNAs that were association with cardiometabolic traits using multi-omics approach and being tested with additional in silico analysis. Proxy: Number of proxy SNPs (R² > 0.8) in strong linkage disequilibrium (LD) with the given variant. Non-synonymous: Number of non-synonymous variants that are in high LD with the given variant. GWAS: (√ SNP represented to be top SNP with the strongest association with the related trait on the certain genomic position). miR-eQTM: CpG is associated with expression level of miRNA.