Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 27;11:220. doi: 10.3389/fimmu.2020.00220

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Vettori, Barra, Russo, Borgia, Pasquale, Pellecchia, Vicedomini and De Palma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Profibrotic gene levels in co-cultured fibroblasts from early dcSSc patients and PCI in co-culture supernatants. Results in panels (A–C) and (E,F) are fold changes in mRNA levels of the profibrotic genes COL1A1, COL3A1, and CTGF, and of the two key mediators of the TGF-β signaling TGFBR2 and SMAD3 in real-time PCR. All show the expression of the investigated genes in fibroblasts co-cultured with autologous PBMCs and hrIL-2 20 U/ml as compared to control fibroblasts. Data are median and IQR ranges, Wilcoxon signed rank test. Results in panel (D) are concentrations as expressed in pg/ml in sandwich ELISA. Data are mean ± SD, paired Student's t-test. *p < 0.05; **p < 0.01; ***p < 0.001; number of samples per group = 5.