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. 2020 Feb 27;10:1406. doi: 10.3389/fgene.2019.01406

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Copyright © 2020 Vallejos-Vidal, Reyes-Cerpa, Rivas-Pardo, Maisey, Yáñez, Valenzuela, Cea, Castro-Fernandez, Tort, Sandino, Imarai and Reyes-López

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of single-nucleotide polymorphism (SNP) c.205A > G effect on the predicted S. salar GSTO-1 (sGSTO-1) structure by homology modeling. (A) Predicted tridimensional sGSTO-1 including the S26G substitution (sGSTO-1 S26G). (B) sGSTO-1 and sGSTO-1 S26P overlay. The punctual amino acid substitution (dotted arrow line) and the region of the secondary structure affected (β2 sheet, circle) are indicated. (C) Enlarged view of the sGSTO-1 S26P substitution shown in (B). sGSTO-1 (transparent) and sGSTO-1 (colored) are shown. The reduced glutathione (GSH) molecule is represented. (D) Ramachandran plot for the predicted sGSTO-1 S26G structure. The amino acid distribution into most favored regions (A,B,L), additional allowed regions (a,b,l,p), generously allowed regions (~a,~b,~l,~p), and disallowed regions (GLU83, ASP97) is indicated.