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. 2020 Jan 6;10(3):967–983. doi: 10.1534/g3.119.400963

Table 3. KEGG and Reactome Pathways that are uniquely enriched in the 16 lists of genes that are either induced or repressed by mating in female head tissues. If a list is not present that indicates that there were no unique enriched pathways identified. Females are either tud/+ (with or without a germline) mated to Berlin males, or Berlin mated to males that are tud/+ (with or without a germline).

Description of biological conditions for each list Pathway p-value No. of Genes
Induced genes Ribosome biogenesis in eukaryotes 5.60E-03 16
Female tud/+ with germline
1-day post-mating
Repressed genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 1.72E-02 7
Female tud/+ with germline Post-translational protein phosphorylation 1.72E-02 7
3-day post-mating HuR (ELAVL1) binds and stabilizes mRNA 1.92E-02 3
Induced genes Metabolism of carbohydrates 3.17E-11 50
Pentose and glucuronate interconversions 1.27E-04 17
Pentose phosphate pathway 1.49E-04 12
Glycolysis / Gluconeogenesis 1.63E-04 19
Glucose metabolism 1.69E-04 18
Gluconeogenesis 2.28E-04 14
Metabolism of RNA 2.67E-04 94
Pentose phosphate pathway (hexose monophosphate shunt) 3.51E-04 9
Metabolism of vitamins and cofactors 6.36E-04 28
Amino acid synthesis and interconversion (transamination) 6.38E-04 10
Propanoate metabolism 8.52E-04 11
Female tud/+ with no germline Metabolism of water-soluble vitamins and cofactors 1.34E-03 24
Fructose and mannose metabolism 1.41E-03 13
Triglyceride metabolism 1.42E-03 8
Catabolism of glucuronate to xylulose-5-phosphate 2.65E-03 6
Galactose metabolism 3.10E-03 12
COPI-dependent Golgi-to-ER retrograde traffic 6.55E-03 11
Pyruvate metabolism 9.49E-03 15
Metabolism of folate and pterines 1.46E-02 9
Metabolism of proteins 1.57E-02 152
Metabolism of polyamines 1.64E-02 20
beta-Alanine metabolism 2.07E-02 8
3-day post-mating Arginine and proline metabolism 2.27E-02 15
Plasma lipoprotein assembly, remodeling, and clearance 2.56E-02 10
Amino sugar and nucleotide sugar metabolism 2.71E-02 14
ABC-family proteins mediated transport 3.09E-02 12
Starch and sucrose metabolism 3.09E-02 16
Peroxisome 3.53E-02 17
Ascorbate and aldarate metabolism 3.94E-02 10
Fructose biosynthesis 3.95E-02 3
Urea cycle 3.95E-02 3
Ethanol oxidation 3.95E-02 3
Triglyceride biosynthesis 4.67E-02 5
Repressed genes Transmission across Chemical Synapses 9.94E-07 19
Female tud/+ with no germline Neurotransmitter release cycle 1.50E-04 9
3-day post-mating Signaling by GPCR 3.03E-03 25
Signal Transduction 3.65E-03 54
Acetylcholine binding and downstream events 4.32E-03 5
Glutamate Neurotransmitter Release Cycle 4.32E-03 5
Postsynaptic nicotinic acetylcholine receptors 4.32E-03 5
Activation of Nicotinic Acetylcholine Receptors 4.32E-03 5
Phototransduction - fly 1.35E-02 7
G alpha (q) signaling events 1.39E-02 6
GPCR downstream signaling 1.43E-02 12
Nephrin family interactions 1.47E-02 5
Acetylcholine Neurotransmitter Release Cycle 1.47E-02 4
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 1.78E-02 4
DARPP-32 events 2.49E-02 3
Neurotransmitter receptors and postsynaptic signal transmission 2.56E-02 9
Collagen degradation 2.75E-02 4
Reelin signaling pathway 2.75E-02 4
Ca2+ pathway 2.78E-02 5
Axon guidance 3.10E-02 20
Developmental Biology 3.26E-02 23
Extracellular matrix organization 3.26E-02 9
PLC beta mediated events 3.71E-02 6
Hemostasis 3.79E-02 23
Basigin interactions 3.95E-02 5
G-protein mediated events 4.11E-02 6
Induced genes ECM-receptor interaction 2.91E-02 4
Berlin female mated to male tud/+ with germline Association of TriC/CCT with target proteins during biosynthesis 2.91E-02 4
1-day post-mating Sulfur amino acid metabolism 3.59E-02 5
Lysine catabolism 4.63E-02 4
Induced genes Tryptophan catabolism 2.70E-02 4
Berlin female mated to male tud/+ with no germline
3-day post-mating
Repressed genes Smooth Muscle Contraction 2.14E-04 6
Berlin female mated to male tud/+ with no germline Muscle contraction 3.99E-03 6
3-day post-mating FCERI mediated Ca+2 mobilization 2.61E-02 3
CLEC7A (Dectin-1) induces NFAT activation 2.61E-02 3