Figure 6.

TUG-891 inhibits phagocytosis of mouse AM via the Gq protein-PLC-Ca²⁺ signaling pathway. Flow cytometry analysis of macrophages that phagocytized the fluorescent microspheres in controls (a) and after TUG-891 treatment (b). Percentage of highly and low phagocytic macrophages (c) and the average fluorescent intensity of macrophages (d). YM-254890, U-73122, thapsigargin, and BAPTA blocked the effects of TUG-891 on increase in low phagocytic cells and decrease in mean intensity of total cells (e, f). ^∗P < 0.05vs. the control, n = 3.