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. 2020 Jan 25;8(3):e1126. doi: 10.1002/mgg3.1126

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© 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Workflow for identification of hub genes and pathways in small cell lung carcinoma and large cell neuroendocrine carcinoma of the lung. Step 1: We identified the differentially expressed genes commonly in small cell lung carcinoma and large cell neuroendocrine carcinoma of the lung. Step 2: The GO and biological pathway analysis were performed and the PPI network was constructed. Next, we identified the hub genes from the PPI network. Step 3: We validated expression patterns and re‐analysis biological pathway of hub genes. Then, the target miRNAs associated with hub genes were identified and gene‐miRNA networks were constructed. Free images were obtained from Servier Medical Art