Figure 2.

Simulation analysis of the splice donor variant results CLRN1 (c.433+1G>A). (a) Best oriented docked pose of the wild‐type RNA with U1 snRNP. The wild‐type RNA and the U1 snRNP are shown in green and red colors, respectively. The wild‐type polymorphism (Guanine) is shown as G21, it is binding with Cytosine 8 of U1 snRNP, (b) The main noncanonical interacting atoms between Guanine (G21) from wild‐type RNA with Cytosine (C8) from U1 snRNP. (c) Noncanonical interactions became less frequent when G21 is mutated to A. Noncanonical interacting atoms are shown as annotated spheres