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Determination of Kd, kon and koff values for two menin inhibitors with a label free, biolayer interferometry assay using an Octet RED system
| Compound | IC50 (nM) to Menin by FP |
Kd (nM) |
kon (105 M−1s−1) |
koff (10−4 s−1) |
|---|---|---|---|---|
| MIV-6 | 229 ± 29 | 110 ± 29 | 4.1 ± 1.1 | 460 ± 102 |
| M-89 | 5.0 ± 1.0 | 1.4 ± 0.6 | 2.3 ± 1.1 | 2.9 ± 0.2 |
