Table 2. Association Between Oral and Topical Terbinafine Use in Pregnancy and Risk of the Primary Outcome Major Malformations in Matched Cohorts on Propensity Scores.
Major Malformations | Total No. of Pregnancies | Malformations, No. (%) | Prevalence OR (95% CI) |
---|---|---|---|
Oral terbinafine exposed vs unexposed matched pregnancies | |||
Oral terbinafine | 522 | 20 (3.8) | 1.01 (0.63-1.62) |
Unexposed | 5220 | 198 (3.8) | 1 [Reference] |
Topical terbinafine exposed vs unexposed matched pregnancies | |||
Topical terbinafine | 1476 | 53 (3.6) | 1.08 (0.81-1.44) |
Unexposed | 14 760 | 491 (3.3) | 1 [Reference] |
Oral vs topical terbinafine-exposed matched pregnancies | |||
Oral terbinafine | 510 | 20 (3.9) | 1.18 (0.61-2.29) |
Topical terbinafine | 510 | 17 (3.3) | 1 [Reference] |
Abbreviation: OR, odds ratio.