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. 2020 Mar 4;156(4):375–383. doi: 10.1001/jamadermatol.2020.0142

Table 2. Association Between Oral and Topical Terbinafine Use in Pregnancy and Risk of the Primary Outcome Major Malformations in Matched Cohorts on Propensity Scores.

Major Malformations Total No. of Pregnancies Malformations, No. (%) Prevalence OR (95% CI)
Oral terbinafine exposed vs unexposed matched pregnancies
Oral terbinafine 522 20 (3.8) 1.01 (0.63-1.62)
Unexposed 5220 198 (3.8) 1 [Reference]
Topical terbinafine exposed vs unexposed matched pregnancies
Topical terbinafine 1476 53 (3.6) 1.08 (0.81-1.44)
Unexposed 14 760 491 (3.3) 1 [Reference]
Oral vs topical terbinafine-exposed matched pregnancies
Oral terbinafine 510 20 (3.9) 1.18 (0.61-2.29)
Topical terbinafine 510 17 (3.3) 1 [Reference]

Abbreviation: OR, odds ratio.