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. 2020 Mar 5;55(3):1802456. doi: 10.1183/13993003.02456-2018

FIGURE 5.

FIGURE 5

Roadmap of antibacterial efficacy testing in mouse models of respiratory infection. The preclinical platform for antibacterial efficacy testing includes acute and chronic infection models and different treatment regimens. Multiple end points, including profiling of bacterial and host responses, are critical parameters to validate the efficacy of anti-Pseudomonas aeruginosa treatment.