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. 2019 Dec;17(12):1146–1157. doi: 10.2174/1570159X17666190726115623

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© 2019 Bentham Science Publishers

This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Fig. (1) — Repair of DSBs through HR and NHEJ. (left) MRN activates DNA cutting to generate 3’ ssDNA overhang which is later wrapped by RPA for protection. Then BRCA2 mediates RAD51 to form nucleoprotein filament. Strain is synthesized after invasion of template DNA. (right) DNA-PKcs is recruited to form DNA-PK after Ku70/80 recognizes break sites. DNA-PK arranges broken ends to get close correctly. Artemis nuclease cuts the overhang and hairpin sequences. Then broken ends are connected by XRCC4-XLF-Lig IV. (A higher resolution / colour version of this figure is available in the electronic copy of the article).