Table 3.

CYP2C9 Tier 1 Variant Alleles

Allele	Allele functional status†	Defining functional variant	HGVS nomenclature: NM_000771.3	HGVS nomenclature: NG_008385.1‡	Reference material available§	Multiethnic allele frequency
*2¶	Decreased function	rs1799853	c.430C>T, p.Arg144Cys	g.8633C>T	Yes	0%–12%
*3‖	Decreased function	rs1057910	c.1075A>C, p.Ile359Leu	g.47639A>C	Yes	1%–11%
*5	Decreased function	rs28371686	c.1080C>G, p.Asp360Glu	g.47644C>G	Yes	0%–1%
*6	No function	rs9332131	c.818del, p.Lys273Argfs*34	g.15625delA	Yes	0%–1%
*8	Decreased function	rs7900194	c.449G>A, p.Arg150His	g.8652G>A	Yes	0%–5%
*11	Decreased function	rs28371685	c.1003C>T, p.Arg335Trp	g.47567C>T	Yes	0%–2%

HGVS, Human Genome Variation Society.

^†Citations for assignment of function can be found at https://www.pharmvar.org/gene/CYP2C9 (last accessed August 15, 2018).

^‡CYP2C9 RefSeqGene.

^§Table 2.

^¶Note that the defining variant of the *35 allele (c.374G>T, p.Arg125Leu) is likely in linkage disequilibrium with the defining *2 variant (c.430C>T, p.Arg144Cys)).

^‖Note that the defining *18 variant of the allele (c.1190A>C, p.Asp397Ala, rs72558193) is likely in linkage disequilibrium with the defining variant of *3 variant (c.1075A>C, p.Ile359Leu, rs1057910).