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. 2020 Feb 27;11:95. doi: 10.3389/fendo.2020.00095

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Copyright © 2020 Ong, Brunmeir, Zhang, Peng, Idris, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HATs that are involved in brown adipocyte differentiation/adipogenesis and adaptive thermogenesis, as well as compounds (HATis) that have been demonstrated to inhibit them. (A) GCN5/PCAF and CBP/p300 mediate brown adipocyte differentiation/adipogenesis by inducing the expression of PPARγ-target, BAT-selective, thermogenic and adipogenic genes through PRDM16 and MLL3/MLL4, respectively, as well as PPARγ. (B) TIF2, SRC-1 and p/CIP mediate adaptive thermogenesis by inducing the expression of BAT-specific PPARγ-target genes. SRC-1 and p/CIP have also been shown to interact with each other to regulate the expression of these genes.