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Crystal structure of p300 catalytic domain in complex with CoA, containing PEG1 and PEG2 (PDB code: 4PZR). p300 is shown in pink, CoA is shown as green sticks, and the PEG moieties are shown as cyan sticks. (A) Overall structure of p300–CoA catalytic domain comprising a central β-sheet and α-helices around it. (B) Surface of the catalytic site and the region surrounding it. The shallow, negatively charged groove composed of Ser1396, Tyr1397, Thr1357, and Asp1625 is colored in purple.
