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. 2020 Feb 27;11:95. doi: 10.3389/fendo.2020.00095

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Copyright © 2020 Ong, Brunmeir, Zhang, Peng, Idris, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural features of human HDACs. (A) Zinc- and NAD⁺-dependent classes HDACs: Catalytic domains of zinc-dependent HDAC2–SAHA (PDB code: 4LXZ) comprising an arginase fold colored in orange, and NAD⁺-dependent SIRT2 (PDB code: 1J8F) comprising a Rossmann fold colored in red. (B) Class IIa HDACs: HDAC4–TFMK inhibitor (PDB code: 2VQJ) and HDAC7–TSA (PDB code: 3C10) structures comprising a catalytic zinc-binding domain and an additional structural zinc-binding domain. The structural zinc ions are coordinated by histidine and cysteine residues shown as sticks.