Figure 6.

Structural features of the class IIb HDAC, HDAC6 ZnF-UBD. (A) Overall structure of the ZnF-UBD of HDAC6 (PDB code: 3C5K). (B) Surface representation of inhibitor-bound human HDAC6 ZnF-UBD (PDB code: 5WBN). The electrostatic potential map shows the inhibitor-bound primary binding pocket, and the opening of a secondary cavity that can be potentially targeted to increase inhibitor selectivity. Basic, acidic and hydrophobic regions are shown in blue, red, and white, respectively. The inhibitor is shown as green sticks.