Figure 5.

H114/Y116 Residue Combination Is Conserved Exclusively across All HLA I Members of the A2 and A24 Superfamilies

(A) Amino acid sequence alignment across members of all HLA-A superfamilies, spanning residues 1–12 and 72–120; residues 114 and 116 (red) as well as residues 12 and 105 (blue) were highlighted.

(B) PyMOL image of the structure of HLA-A^∗68:02 folded with peptide SVYDFFVWL (PDB ID 4HX1); residues H114 and Y116 are highlighted in red, the L9 residue of the peptide in light blue, and the peptide backbone in gray. Dotted yellow lines indicate the shortest distances between the connected amino acid residues, measured in Å.