Figure 7.

Foxp3⁺ Cells Were Found in Hepatocytes More Frequently Than Tbet⁺ Cells in Donor Livers and in Explants from Patients with Chronic Liver Disease

(A) Immunohistochemistry images of Foxp3⁺ and Tbet⁺ cells (DAB, brown) in livers from a patient with autoimmune hepatitis (AIH).

(B and C) Absolute numbers (B) and frequencies (C) of Foxp3⁺ or Tbet⁺ CD4⁺ T cells in hepatocytes in immunohistochemistry-stained sections from 80 patients with end-stage liver disease. Manual counts were performed by two independent scientists. PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; ALD, alcoholic liver disease; NASH, non-alcoholic steatohepatitis; HBV, hepatitis B virus infection; HCV, hepatitis C virus infection. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001, Student’s non-parametric paired t test (Wilcoxon).