Comparison 6. Cryoablation (second generation) versus rollerball (first generation).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Bleeding	1	228	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.36, 0.69]
1.1 Amenorrhoea at 1 year follow‐up	1	228	Risk Ratio (M‐H, Fixed, 95% CI)	0.50 [0.36, 0.69]
2 Rate of satisfaction	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 At 1 year follow‐up	1	279	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.96, 1.17]
2.2 At 2 years' follow‐up	1	137	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.91, 1.17]
3 Proportion given local anaesthesia (%)	1	279	Risk Ratio (M‐H, Fixed, 95% CI)	6.62 [3.22, 13.63]
4 Complication rate: major complications	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Perforation	1	279	Risk Ratio (M‐H, Fixed, 95% CI)	0.15 [0.01, 3.63]
5 Complication rate: minor complications	1	1116	Odds Ratio (M‐H, Fixed, 95% CI)	0.56 [0.15, 2.09]
5.1 Vaginal bleeding	1	279	Odds Ratio (M‐H, Fixed, 95% CI)	1.35 [0.05, 33.43]
5.2 Abdominal cramping	1	279	Odds Ratio (M‐H, Fixed, 95% CI)	2.26 [0.11, 47.54]
5.3 UTI	1	279	Odds Ratio (M‐H, Fixed, 95% CI)	0.15 [0.01, 3.65]
5.4 Severe pelvic pain	1	279	Odds Ratio (M‐H, Fixed, 95% CI)	0.15 [0.01, 3.65]
6 Requirement for further surgery	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 At 2 years' follow‐up (any surgery)	1	279	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.45, 2.22]
6.2 At 2 years' follow‐up (hysterectomy)	1	279	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.34, 2.00]