Quality of life ‐ change in SF‐36 score after treatment
Study	MEA	TCRE	Results
Physical functioning
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 0.7 (18.9) AT 2 YEARS: N=120 Mean change (SD): 2.3 (21.3) AT 5 YEARS: N=116 Mean change (SD): 0.2 (24) At 10 YEARS: N=94 Mean change (SD): ‐4.4 (27)	AT 1 YEAR: N=124 Mean change (SD): 2.4 (16.8) AT 2 YEARS: N=129 Mean change (SD): 0.9 (20.4) AT 5 YEARS: N=120 Mean change (SD): ‐1.2 (21) At 10 YEARS: N=95 Mean change (SD): ‐3.0 (25)	AT 1 YEAR: t test: CI (‐6.4, 2.9); P=0.45 Ancova: P=0.58 AT 2 YEARS: t test: P=0.28 (95% CI ‐3.8, 6.6) AT 5 YEARS: t test: NS (95% CI ‐4.5 to 7.3) At 10 YEARS: t test: NS (95% CI ‐8.9 to 6.1)
Social functioning
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 20.6 (26.5) AT 2 YEARS: N=120 Mean change (SD): 10.1 (27.5) AT 5 YEARS: N=116 Mean change (SD): 7.7 (30) At 10 YEARS: N=94 Mean change (SD): 10.1 (30)	At 1 YEAR: N=124 Mean change (SD): 16.2 (24.4) AT 2 YEARS: N=129 Mean change (SD): 6.2 (23.7) AT 5 YEARS: Mean change (SD): 9.7 (25) At 10 YEARS: N=95 Mean change (SD): 9.9 (26)	AT 1 YEAR: t test: CI (‐2.1, 10.90): P=0.18 Ancova: P=0.12 AT 2 YEARS: t test: P=0.33 (95% CI ‐2.5, 10.3) AT 5 YEARS: t test: NS (95% CI ‐9.0 to 5.0) At 10 YEARS: t test: NS (95% CI ‐7.9 to 8.3)
Physical role
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 23.9 (49.4) AT 2 YEARS: N=120 Mean change (SD): 18.5 (53.7) AT 5 YEARS: N=116 Mean change (SD): 17 (54) At 10 YEARS: N=94 Mean change (SD): 15.0 (53)	AT 1 YEAR: N=124 Mean change (SD): 11.3 (41.7) AT 2 YEARS: N=129 Mean change (SD): 6.1 (43.8) AT 5 YEARS: N=120 Mean change (SD): 11 (43) At 10 YEARS: N=95 Mean change (SD): 10.9 (47)	AT 1 YEAR: t test: CI (1.0 to 24.3); P=0.03 Ancova: P=0.03 AT 2 YEARS: t test: P=0.06 (95% CI ‐0.2, 24.6) AT 5 YEARS: t test: NS, 95% CI ‐5.8 to 19 At 10 YEARS: t test: NS, 95% CI ‐10.3 to 18.5
Emotional role
Cooper 1999	AT ONE YEAR: N=116 Mean change (SD): 17.0 (48.5) AT 2 YEARS: N=120 Mean change (SD): 17.8 (47.5) AT 5 YEARS: N=116 Mean change (SD): 19 (48) At 10 YEARS: N=94 Mean change (SD): 21.1 (50)	AT 1 YEAR: N=124 Mean change (SD): 13.7 (47.9) AT 2 YEARS: N=129 Mean change (SD): 4.2 (40.1) AT 5 YEARS: N=120 Mean change (SD): 20 (41) At 10 YEARS: N=95 Mean change (SD): 13.5 (47)	AT 1 YEAR: t test: CI (‐9.1 to 15.6); P=0.59 Ancova: P=0.38 AT 2 YEARS: t test P=0.17 (95% CI ‐3.6, 23.5) AT 5 YEARS: t test: NS, 95% CI ‐13 to 10 At 10 YEARS: t test: NS, 95% CI 6.3 to 21.5
Mental health
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 6.3 (19.5) AT 2 YEARS: N=120 Mean change (SD): 6.0 (21.6) AT 5 YEARS: N=116 Mean change (SD): 1.4 (21) At 10 YEARS: N=94 Mean change (SD): 7.2 (21)	AT 1 YEAR: N=124 Mean change (SD): 6.0 (22.2) AT 2 YEARS: N=129 Mean change (SD): 4.1 (19.8) AT 5 YEARS N=120 Mean change (SD): 1.2 (21) At 10 YEARS: N=95 Mean change (SD): 7.9 (25)	AT 1 YEAR: t test: CI (‐4.9 to 5.7); P=0.89 Ancova: P=0.83 AT 2 YEARS: t test: P=0.44 (95% CI ‐3.3, 6.9) AT 5 YEARS: t test: NS, 95% CI ‐5.2 to 5.6 At 10 YEARS: t test: NS, 95% CI ‐7.3 to 5.9
Energy/fatigue
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 12.8 (21.7) AT 2 YEARS: N=120 Mean change (SD): 11.4 (25.1) AT 5 YEARS: N=116 Mean change (SD): 9.3 (25) At 10 YEARS: N=94 Mean change (SD): 12.9 (29)	AT 1 YEAR: N=124 Mean change (SD): 12.1 (23.0) AT 2 YEARS: N=129 Mean change (SD): 11.8 (22.6) AT 5 YEARS: N=120 Mean change (SD): 12 (26) At 10 YEARS: N=95 Mean change (SD): 15.3 (27)	AT 1 YEAR: t test: CI (‐4.9 to 6.5); p=0.80 Ancova: p=0.58 AT 2 YEARS: t test: P=0.90 (95% CI ‐6.4, 5.5) AT 5 YEARS: t test: NS, 95% CI ‐9.1 to 4.2 At 10 YEARS: t test: NS, 95% CI ‐10.4 to 5.6
Pain
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 14.8 (31.0) AT 2 YEARS: N=120 Mean change (SD): 13.5 (31.7) AT 5 YEARS: N=116 Mean change (SD): 9.3 (35) At 10 YEARS: N=94 Mean change (SD): 11.6 (37)	AT 1 YEAR: N=124 Mean change (SD): 7.2 (31.1) AT 2 YEARS: N=129 Mean change (SD): 3.0 (29.8) AT 5 YEARS: N=120 Mean change (SD): 6.4 (31) At 10 YEARS: N=95 Mean change (SD): 12.3 (35)	AT 1 YEAR: t test: CI (‐0.2 to 15.5); P=0.06 Ancova: P=0.54 AT 2 YEARS: t test: P=0.02 (95% CI 2.9, 18.2) AT 5 YEARS: t test: NS, 95% CI ‐5.7 to 12 At 10 YEARS: t test: NS, 95% CI ‐11.0 to 9.6
General health
Cooper 1999	AT 1 YEAR: N=116 Mean change (SD): 2.4 (20.3) AT 2 YEARS: N=120 Mean change (SD): 0.0 (24.4) AT 5 YEARS: N=116 Mean change (SD): ‐3.3 (26) At 10 YEARS: N=94 Mean change (SD): 0.94 (23)	AT 1 YEAR: N=124 Mean change (SD): ‐2.9 (20.0) AT 2 YEARS: N=129 Mean change (SD): ‐2.9 (19.0) AT 5 YEARS: N=120 Mean change (SD): ‐2.4 (19) At 10 YEARS: N=95 Mean change (SD): 2.8 (22)	AT 1 YEAR: t test: CI (0.2 to 10.5); P=0.04 Ancova: P=0.06 AT 2 YEARS: t test: P=0.29 (95% CI ‐2.5, 8.4) AT 5 YEARS: t test: NS, 95% CI ‐6.5 to 4.9 At 10 YEARS: t test: NS, 95% CI ‐8.3 to 4.6