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. 2019 Jan 22;2019(1):CD001501. doi: 10.1002/14651858.CD001501.pub5

McClure 1992.

Methods Single‐centre study, parallel‐group design with unclear blinding
Participants 38 women initially recruited for trial; mean age 42 years; from tertiary referral centre at University Department, Monash University
 12 excluded before randomisation because of prior MBL measurements < 70 mL; 4 dropped out because of dissatisfaction with operative delay
 Inclusion criteria:
  • Subjective diagnosis of menorrhagia unresponsive to medical therapy

  • Normal cervical cytology

  • MBL ≥ 70 mL (alkaline haematin method)


Exclusion criteria:
  • Fibroid enlargement

  • Other intrauterine pathology


Setting: tertiary referral centre, University department
Timing: between May 1989 and July 1991
Interventions All participants had pelvic examination and transvaginal ultrasonography
Those randomised also received preoperative treatment with 10 mg MPA 3 times/d for 3 months to thin the endometrium
  • Laser (argon) ablation (n = 12)

  • TCRE + rollerball (n = 10)


Duration: 6 months
Outcomes • Reduction in MBL
• Duration of surgery
• Postoperative complications and requirement for analgesia
• Need for further surgery
• Amenorrhoea rate
Notes No power calculation for sample size
Source of funding: not stated
Conflicts of interest: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method not stated
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Unlikely
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Unlikely
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No dropouts reported but very small study
Selective reporting (reporting bias) Low risk All prespecified outcomes reported
Other bias Low risk No evidence of other biases; source of funding not reported; groups appeared balanced at baseline