McClure 1992.
Methods | Single‐centre study, parallel‐group design with unclear blinding | |
Participants | 38 women initially recruited for trial; mean age 42 years; from tertiary referral centre at University Department, Monash University
12 excluded before randomisation because of prior MBL measurements < 70 mL; 4 dropped out because of dissatisfaction with operative delay
Inclusion criteria:
Exclusion criteria:
Setting: tertiary referral centre, University department Timing: between May 1989 and July 1991 |
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Interventions | All participants had pelvic examination and transvaginal ultrasonography Those randomised also received preoperative treatment with 10 mg MPA 3 times/d for 3 months to thin the endometrium
Duration: 6 months |
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Outcomes | • Reduction in MBL • Duration of surgery • Postoperative complications and requirement for analgesia • Need for further surgery • Amenorrhoea rate |
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Notes | No power calculation for sample size Source of funding: not stated Conflicts of interest: not reported |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method not stated |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Unlikely |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Unlikely |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No dropouts reported but very small study |
Selective reporting (reporting bias) | Low risk | All prespecified outcomes reported |
Other bias | Low risk | No evidence of other biases; source of funding not reported; groups appeared balanced at baseline |