Fig. 4.

Mindful acceptance modulates response to painful heat. (a) Regions responsive to painful heat identified in the contrast Hot vs. Warm Temperatures. Red/yellow colors indicate greater activity during Hot than Warm Temperatures; yellow regions indicate the most significant differences. (b) Regions modulated by mindful acceptance in the contrast ACCEPT vs. REACT for hot temperatures only. Blue/green colors indicate greater activity in REACT than ACCEPT; green regions indicate the most significant differences. (c) Regions of overlap found in conjunction of (a) and (b). (d–e) Extracted time courses from insula and thalamus regions identified in the conjunction (b)—peaks are shifted due to HRF/BOLD delay. All results are family-wise error corrected at P < .05. Right is displayed on the right.