Table 1.
Regions showing differential activation based on instruction. R/L/Bi refers to lateralization of activation. x, y and z are MNI peak coordinates. mm3 refers to the spatial extent of each cluster, expressed as cubic millimeters (3 × 3 × 3 mm/voxel * number of voxels). (A–D) Peak/mean statistics are t values. Results are whole-brain family-wise error-corrected at p < 0.05. (E–F) Peak statistics for conjunctions represent the minimum (less significant) t value of the two maps and average minimum t statistic in the cluster, following conjunction conventions (Nichols et al., 2005)
| Peak coordinates | |||||||
|---|---|---|---|---|---|---|---|
| Regions of Activation | R/L/Bi | x | y | z | mm 3 | Peak statistic | Mean statistic |
| A. Negative images > neutral images | |||||||
| Temporal/occipital/parietal | Bi | −45 | −66 | 3 | 164 538 | 11.43 | 4.36 |
| Middle/inferior frontal/precentral gyrus | R | 45 | 36 | 9 | 33 966 | 8.68 | 4.17 |
| Dorsal anterior/posterior cingulate gyrus/dorsal medial frontal gyrus | L | −6 | 9 | 27 | 25 893 | 7.54 | 3.71 |
| Amygdala/thalamus/putamen/parahippoca mpal gyrus/midbrain | Bi | 24 | −30 | −9 | 18 495 | 6.83 | 3.66 |
| Postcentral gyrus | R | 15 | −48 | 72 | 5022 | −4.40 | −3.44 |
| Insula/inferior/middle frontal gyrus | L | −30 | 24 | −15 | 4995 | 5.44 | 3.66 |
| Superior temporal gyrus | R | 69 | −12 | −3 | 3537 | −5.38 | −3.57 |
| Middle frontal/precentral gyrus | L | −45 | 0 | 24 | 2781 | 4.77 | 3.54 |
| Middle/superior temporal gyrus | L | −66 | −39 | −3 | 2187 | −4.88 | −3.62 |
| Superior/middle temporal gyrus | L | −54 | −21 | −3 | 1620 | −4.68 | −3.39 |
| B. Accept > react for negative images | |||||||
| Superior/middle temporal gyrus | R | 42 | 21 | −24 | 4212 | −5.54 | −3.55 |
| Medial/superior frontal gyrus | Bi | −3 | 63 | −6 | 1890 | −5.43 | −3.53 |
| Amygdala/midbrain | R | 12 | −18 | −15 | 1647 | −5.09 | −3.53 |
| C. Painfully hot > warm temperatures | |||||||
| Dorsal anterior cingulate/medial frontal | |||||||
| Gyrus/precentral and postcentral gyrus/anterior and posterior insula/ thalamus/inferior parietal/parahippocampal gyrus/putamen/caudate/midbrain/cerebellum | Bi | 54 | −21 | 27 | 236 358 | 8.01 | 3.76 |
| Cuneus/lingual gyrus | L | −3 | −78 | 9 | 14 229 | 5.08 | 3.42 |
| Cerebellum | R | 39 | −42 | −36 | 2268 | 6.24 | 3.73 |
| Pre-SMA/middle frontal gyrus | R | 45 | 6 | 39 | 1782 | 4.07 | 3.24 |
| D. Accept > react for painful heat | |||||||
| Anterior and posterior insula/dorsal anterior cingulate/medial frontal gyrus/precentral and postcentral gyrus/inferior parietal/precuneus/posterior cingulate | Bi | 51 | −24 | 18 | 52 029 | −6.03 | −3.46 |
| Cerebellum/middle and inferior occipital | L | −45 | −81 | −21 | 4806 | −5.29 | −3.41 |
| Cerebellum/cuneus/posterior cingulate | R | 3 | −45 | 0 | 4698 | −4.61 | −3.49 |
| Cerebellum/middle and inferior occipital | R | 57 | −66 | −15 | 3996 | −5.17 | −3.39 |
| Thalamus | L | −12 | −27 | 9 | 2970 | −5.51 | −3.41 |
| Middle temporal gyrus/middle occipital | R | 45 | −72 | 15 | 2646 | −5.14 | −3.50 |
| Mid insula/precentral gyrus | R | 63 | 9 | 0 | 2484 | −5.89 | −3.54 |
| Inferior parietal lobule | R | 72 | −33 | 24 | 1836 | −4.32 | −3.29 |
| Caudate | R | 15 | 0 | 21 | 1620 | −5.56 | −3.75 |
| E. Conjunction: (A. negative images > neutral images) and (B. accept > react for negative images) | |||||||
| Amygdala | R | 21 | −9 | −12 | 567 | −4.46 | −3.57 |
| F. Conjunction: (C. painfully hot > warm temperatures) and (D. accept > react for painful heat) | |||||||
| Posterior insula/postcentral gyrus | L | −60 | −27 | 21 | 3456 | 4.67 | 3.41 |
| Caudate/thalamus | R | 15 | −3 | 21 | 1350 | 4.70 | 3.48 |
| Mid insula | L | −30 | −3 | 9 | 1242 | 5.19 | 3.53 |
| Posterior insula/postcentral gyrus | R | 54 | −24 | 18 | 1080 | 4.90 | 3.60 |
| Superior temporal gyrus | L | −57 | 0 | 0 | 999 | 3.75 | 3.21 |
| Paracentral lobule | R | 12 | −27 | 48 | 756 | 4.02 | 3.33 |
| Postcentral gyrus | R | 69 | −21 | 27 | 702 | 3.54 | 3.17 |
| Posterior cingulate | R | 6 | −33 | 24 | 621 | 3.65 | 3.23 |