Table 1.

Tag single nucleotide polymorphisms spanning the KL gene region (±20 kb) significantly associated with pressure natriuresis at time 120 minutes

SNP Rank	rs Code	Chr 13 Position (bp)	Alleles	Minor Allele	MAF	P Valuea	Homozygotes for the Major Alleleb	Heterozygotesb	Homozygotes for the Minor Alleleb
1	rs446647	33571078	T/C	C	0.22	0.69	0.007±0.036	0.006±0.026	0.002±0.016
2	rs367243	33578412	G/A	A	0.20	0.74	0.007±0.036	0.005±0.026	0.005±0.014
3	rs526906	33598987	C/T	T	0.14	0.37	0.006±0.027	0.003±0.045	0.008±0.019
4	rs480830	33606723	T/C	C	0.46	0.49	0.007±0.029	0.008±0.037	0.003±0.026
5	rs9526984	33609937	A/G	G	0.09	0.02	0.005±0.032	0.015±0.032	0.023±0.033
6	rs1334928	33615948	T/G	G	0.38	0.09	0.010±0.032	0.003±0.035	0.006±0.023
7	rs2320762	33617174	T/G	G	0.41	0.07	0.003±0.040	0.010±0.026	0.006±0.028
8	rs657049	33622817	A/G	G	0.28	<0.001c	0.006±0.025	0.003±0.036	0.026±0.045
9	rs9527026	33628239	G/A	A	0.15	<0.000446c	0.004±0.032	0.011±0.025	0.036±0.065
10	rs9315202	33642016	C/T	T	0.30	0.06	0.006±0.039	0.010±0.021	−0.001±0.032
11	rs581971	33644398	G/A	A	0.47	0.61	0.008±0.029	0.005±0.038	0.007±0.022
12	rs670657	33649054	G/A	A	0.17	0.59	0.007±0.027	0.004±0.043	0.008±0.015
13	rs9536357	33651505	G/A	A	0.46	0.20	0.003±0.041	0.008±0.023	0.009±0.035
14	rs9591501	33658270	C/T	T	0.09	0.08	0.005±0.032	0.013±0.033	0.023±0.029
15	rs566996	33660785	G/A	A	0.25	0.58	0.008±0.037	0.004±0.024	0.008±0.029

SNPs are ranked by chromosome and position based on the GRCh37 (release 105) assembly. Chr13, chromosome 13; MAF, minor allele frequency.

^aNominal P value of association.

^bPressure natriuresis at time 120 minutes is expressed as mean±SD, adjusted for age, sex, and body mass index.

^cP<0.003, adjusted P value threshold after Bonferroni multiple comparison test.