Table 3.

Effect of acute saline load in the discovery cohort of patients with treatment-naive hypertension according to KL rs9536314 genotypes

Parameters	KL TG+GG (n=179)	KL TT (n=494)	P ANOVA
Baseline
Systolic BP, mm Hg	138±14	140±15	0.12
Diastolic BP, mm Hg	89±10	91±10	0.11
Mean BP, mm Hg	106±10	107±11	0.08
Urinary sodium, mEqa	17±14	16±15	0.35
Urinary potassium, mEqa	7.5±7.4	7.0±8.2	0.51
PRA, ng/ml per hour	1.7±1.5	2.0±2.0	0.11
Plasma aldosterone, ng/dl	170±112	172±121	0.86
End of infusion (time 120 minutes)
Systolic BP, mm Hg	144±15	144±16	0.76
Diastolic BP, mm Hg	92±11	92±12	0.89
Mean BP, mm Hg	110±12	109±12	0.91
Urinary sodium, mEqb	55±33	53±31	0.51
Urinary potassium, mEqb	13±10	11±7	0.08
End of recovery time (time 240 minutes)
PRA, ng/ml per hour	0.6±0.5	0.6±0.5	0.92
Plasma aldosterone, ng/dl	51±43	55±49	0.40
Change from baseline
Systolic BP, mm Hgd	5.6±8.7	3.2±9.3	0.003c
Diastolic BP, mm Hgd	2.3±6.1	0.9±6.2	0.01c
Mean BP, mm Hgd	3.4±6.3	1.7±6.4	0.002c
Urinary sodium, mEqd	37±33	37±30	0.82
Urinary potassium, mEqd	4.9±11	4.4±8.6	0.57
PRA, ng/ml per houre	−1.1±0.1	−1.4±0.09	0.11
Plasma aldosterone, ng/dle	−121±8	−123±5	0.81

Normally distributed numeric data are expressed as mean±SD. PRA, plasma renin activity.

^aExcretion during equilibration period (time −120/0 minutes).

^bExcretion during infusion period (time 0/120 minutes).

^cP<0.05.

^dChange from baseline to time 120 minutes (end of infusion period) for systolic BP, diastolic BP, mean BP, urinary sodium, and urinary potassium.

^eChange from baseline to time 240 minutes (end of recovery time) for PRA and aldosterone.