Table 4.
Salt-sensitive, pressure-natriuresis slopes by KL rs9536314 genotype in the discovery cohort of patients with treatment-naive hypertension, in the replication cohort, and in the combined cohort
| Cohort | Pressure Natriuresis Slope (mm Hg/μEq per minute) | P ANOVA | |
|---|---|---|---|
| KL Genotype TG+GG | KL Genotype TT | ||
| Discovery cohort (n=673) | 0.013±0.03 (n=179) | 0.004±0.03 (n=494) | 0.001 |
| Replication cohort (n=193) | 0.015±0.04 (n=47) | 0.005±0.03 (n=146) | 0.04 |
| Combined cohort (n=866)a | 0.013±0.03 (n=226) | 0.004±0.03 (n=640) | 0.000146 |
Normally distributed numeric data expressed as mean±SD. Data adjusted for age, sex, and body mass index.
a
The combined cohort was also adjusted for eGFR at baseline.