Table 3. Nomenclature for the omalizumab-derived Fabs and scFv.
| Construct | Sequence | Structure | No. of molecules in the asymmetric unit |
|---|---|---|---|
| FabXol | Wild type | FabXol1 | 1: FabXol1 |
| FabXol2 | 2: FabXol2A, FabXol2B | ||
| FabXol1 | Leu158Pro† | FabXol11 | 2: FabXol11A, FabXol11B |
| FabXol12 | 4: FabXol12A, FabXol12B, FabXol12C, FabXol12D | ||
| FabXol2 | Ser81Arg†, Gln83Arg† | FabXol2 | 1: FabXol2 |
| FabXol3 | Ser81Arg†, Gln83Arg†, Leu158Pro† | FabXol3 | 1: FabXol3 |
| scFvXol | Wild type† | scFvXol | 1: scFvXol |
Mutation in the Fab light chain.
The VL and VH domains are linked by a (Gly4Ser)4 linker.