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. 2020 Mar 2;76(Pt 3):116–129. doi: 10.1107/S2053230X20001466

Table 3. Nomenclature for the omalizumab-derived Fabs and scFv.

Construct Sequence Structure No. of molecules in the asymmetric unit
FabXol Wild type FabXol1 1: FabXol1
    FabXol2 2: FabXol2A, FabXol2B
FabXol1 Leu158Pro FabXol11 2: FabXol11A, FabXol11B
    FabXol12 4: FabXol12A, FabXol12B, FabXol12C, FabXol12D
FabXol2 Ser81Arg, Gln83Arg FabXol2 1: FabXol2
FabXol3 Ser81Arg, Gln83Arg, Leu158Pro FabXol3 1: FabXol3
scFvXol Wild type scFvXol 1: scFvXol

Mutation in the Fab light chain.

The VL and VH domains are linked by a (Gly4Ser)4 linker.