Table 5. Kinetics of omalizumab, the omalizumab-derived Fabs and scFv binding to IgE-Fc.

Molecule immobilized	k on1 (M −1 s−1)	k on2 (M −1 s−1)	k off1 (s−1)	k off2 (s−1)
Omalizumab	3.3 × 105	2.9 × 105	7.0 × 10−4	1.2 × 10−2
FabXol	5.7 × 105	4.4 × 105	5.6 × 10−4	1.2 × 10−2
FabXol2	5.1 × 105	3.3 × 105	4.5 × 10−4	1.1 × 10−2
FabXol3	9.7 × 105	2.7 × 105	3.3 × 10−4	9.0 × 10−3
scFvXol	6.9 × 105	3.1 × 105	2.9 × 10−4	8.7 × 10−3