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. Author manuscript; available in PMC: 2021 Feb 5.
Published in final edited form as: ACS Chem Neurosci. 2020 Jan 22;11(3):242–247. doi: 10.1021/acschemneuro.9b00647

Figure 2.

Figure 2.

Functional validation of α7 nAChR cys-min construct. (A) Agonist concentration response curves of Xenopus oocytes expressing wild-type (wt) α7 nAChR, an α7 nAChR construct with no unpaired cysteines (Cys-min), or a construct with no cysteines (Cys-null). Error bars indicate standard error of means. (B) Representative current traces of Xenopus oocytes expressing wt α7 nAChR or the cys-min construct showing similar desensitization by 1 mM acetylcholine. (C) Representative current traces of Xenopus oocytes injected with RNA for α7 nAChR or the cys-min construct showing potentiation by positive allosteric modulator TQS. Bars indicate application of acetylcholine (20 μM) and TQS (30 μM). Scale bars are 1 μA and 30s.