Figure 3.

Methylation status changes in EXE-resistant (EXEr) and EXE-sensitive (EXEs) groups during EXE treatment. (A), Red: Hierarchical clustering analysis of methylation ratio (MR) variation in all 15 patients and EXEr patients. (B) and (C), Receiver operating characteristic curve analysis shows changes in methylation density (MD) and MR for 7 selected differentially methylated regions. (D-F) Kaplan-Meier survival analyses for MD variation (D) and MR variation (E) and synchronized MD and MR variation (F) of Chr6 [149600000-149799999]. Demethylation: synchronized decrease in MD and MR, Remethylation: synchronized increase in MD and MR. Chr indicates chromosome.