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. 2020 Mar 4;19:1533033819896331. doi: 10.1177/1533033819896331

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Genomic methylation status in MCF-7 human breast cancer cells and in exemestane-resistant MCF-7 (MCF-7/EXE) cells. (A) Viability assay of MCF-7 and MCF-7/EXE cells subjected to increasing concentrations of exemestane. (B) IC₅₀ of MCF-7 and MCF-7/EXE were calculated using cell viability curve. Morphologies of (C) MCF-7 and (D) MCF-7/EXE (magnification: ×200). Comparisons between MCF-7 and MCF-7/EXE for (E) average genomic methylation ratio (MR) and (F) average genomic methylation density (MD). Comparisons between MCF-7 and MCF-7/EXE for (G) MR and (H) MD of chromosome 6 [32400000-32599999].