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. 2020 Jan 19;8(1):e000157. doi: 10.1136/jitc-2019-000157

Figure 2.

Figure 2

Kaplan-Meier survival curves for PFS and OS of patients with ccRCC according to HHLA2 and PD-L1 expression. (A) PFS and OS according to HHLA2 expression status in the training cohort and validation cohort. (B) PFS and OS according to PD-L1 expression status in the training cohort and validation cohort. (C) PFS and OS according to a combination of HHLA2/PD-L1 co-expression. Group I: HHLA2 (−)/PD-L1 (−); group II: HHLA2 (+)/PD-L1 (−) or HHLA2 (−)/PD-L1 (+); group III: HHLA2 (+)/PD-L1 (+). (D) PFS and OS according to new immune classification. Type BI: TILs positive and both negative (HHLA2 (−)/PD-L1 (−)); type BII: TILs positive and single positive (HHLA2 (+)/PD-L1 (−) or HHLA2 (−)/PD-L1 (+)); type BIII: TILs positive and both positive (HHLA2(+)/PD-L1(+)). ccRCC, clear cell renal cell carcinoma; HHLA2, human endogenous retrovirus-H long terminalrepeat-associating protein 2; OS, overall survival; PD-L1, programmed death 1 ligand 1; PFS, progression-free survival; TIL, tumor-infiltrating lymphocyte.