Skip to main content
. 2020 Jan 13;8(1):e000244. doi: 10.1136/jitc-2019-000244

Figure 5.

Figure 5

5FU followed by p50-IMC slows PDC tumor growth. (A) Albino mice inoculated orthotopically with K-RasG12D PDC on day 0 received 5FU on day 7 and 107 WT-IMC or p50-IMC on days 12, 15 and 19 in Exp. 1 or 5FU on day 3 and IMC on days 8, 11 and 14 in Exp. 2 and Exp. 3, as diagrammed. (B) Tumor sizes were monitored by serial in vivo imaging system imaging, with relative bioluminescence shown for each tumor in each experiment. (C) The data from Exp. 2/3 were fit to an exponential model, with semilog plots and comparison of expected mean tumor volumes between the 5FU/WT-IMC and 5FU/p50-IMC on day 14. (D) Mean tumor volumes and SEs as measured on day 14 for these same groups are shown. Exp. 1, experiment 1; Exp. 2, experiment 2; Exp. 3, experiment 3; 5FU, 5-fluorouracil; IMC, immature myeloid cell; p50-IMC, p50-negative immature myeloid cell; PDC, pancreatic ductal carcinoma; WT, wild type.