. 2020 Mar 4;21:242. doi: 10.1186/s13063-020-4163-0

Table 3.

Study assessments

	Admission	Iloprost administration
	Admission	d1	d2	d3	d4	d5	ICU/ IMC	Ward	Hospital discharge or d28	Hospital discharge or d90
Laboratory testing
Blood count	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c	X	X
Procalcitonin	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c	X	X
IL-6	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c	X	X
PaO₂/FiO₂	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c
Hemoglobin	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c	X	X
Hemostasis parameters	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c	X	X
Renal parameters	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X^c	X	X
Clinical parameters
Ventilation support including ventilation parameters	X^a	X^a	X^a	X^a	X^a	X^a	X^a
Prone positioning	X^a	X^a	X^a	X^a	X^a	X^a	X^a
ECMO	X^a	X^a	X^a	X^a	X^a	X^a	X^a
Relaxation	X^a	X^a	X^a	X^a	X^a	X^a	X^a
High-frequency ventilation	X^a	X^a	X^a	X^a	X^a	X^a	X^a
Tracheotomy
Hemodynamic parameters	X^a	X^a	X^a	X^a	X^a	X^a	X^b	X	X	X
Vasopressor therapy	X^a	X^a	X^a	X^a	X^a	X^a	X^a
Inotrope therapy	X^a	X^a	X^a	X^a	X^a	X^a	X^a
Fluid balance	X^a	X^a	X^a	X^a	X^a	X^a	X^a
Transfusion of red blood cells	X	X	X	X	X	X	X^b	X	X	X
Transfusion of thrombocytes	X	X	X	X	X	X	X^b	X	X	X
Anticoagulation
Infection	X	X	X	X	X	X	X^b	X	X	X
Anti-infective therapy	X	X	X	X	X	X	X^b	X	X	X
Length of stay in ICU
Length of stay in hospital
Discharge location									X	X
Death
Cause of death
Scores
Richmond Agitation-Sedation Scale (RASS)	X^a	X^a	X^a	X^a	X^a	X^a	X^a
SOFA score^d	X	X	X	X	X	X	X		X	X
Barthel Index									X	X

IMC intermediate care

^aAssessment on daily basis during ICU stay

^bAssessment on daily basis until day 14 and then once per week during ICU/IMC stay

^cAssessment once per week on ward

^dSOFA score during ventilation support once per week

^eqSOFA score spontaneous breathing