Table 4.
Sustained Virologic Response Rates (95% Confidence Intervals) in Patients infected with HCV Genotype 2, 4, and 6
Genotype 2 SVR, % (95% CI) | Genotype 4 SVR, % (95% CI) | Genotype 6 SVR, % (95% CI) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
All patients | DAC + SOF | SOF/VEL | All patients | LDV/SOF | DAC + SOF | All patients | LDV/SOF | DAC + SOF | SOF/VEL | |
Patients who complete, N | 14 | 10 | 4 | 11 | 1 | 10 | 152 | 36 | 109 | 7 |
All durations | 100 (78.5–100) | 100 (72.2–100) | 100 (51.0–100) | 90.9 (62.3–98.4) | 100 (20.7–100) | 90.0 (59.6–98.2) | 96.7 (92.5–98.6) | 97.2 (85.8–99.5) | 96.3 (90.9–98.6) | 100 (64.6–100) |
12-wk treatment | 100 (77.2–100) | 100 (70.1–100) | 100 (51.0–100) | 87.5 (52.9–97.8) | 100 (20.7–100) | 85.7 (48.7–97.4) | 97.1 (92.9–98.9) | 97.0 (84.7–99.5) | 97.0 (91.5–99.0) | 100 (64.6–100) |
16-wk treatment | NA | NA | NA | NA | NA | NA | 100 (34.2–100) | NA | 100 (34.2–100) | NA |
24-wk treatment | 100 (20.7–100) | 100 (20.7–100) | NA | 100 (43.9–100) | NA | 100 (43.9–100) | 90.0 (59.6–98.2) | 100 (43.9–100) | 85.7 (48.7–97.4) | NA |
SVR in the following subgroups | ||||||||||
No cirrhosis | 100 (74.1–100) | 100 (64.6–100) | 100 (51.0–100) | 100 (61.0–100) | 100 (20.7–100) | 100 (56.6–100) | 96.8 (90.9–98.9) | 100 (82.4–100) | 95.8 (88.5–98.6) | 100 (43.9–100) |
Cirrhosis | 100 (43.9–100) | 100 (43.9–100) | NA | 80.0 (37.6–96.4) | NA | 80.0 (37.6–96.4) | 96.6 (88.5–99.1) | 94.4 (74.2–99.0) | 97.3 (86.2–99.5) | 100 (51.0–100) |
Decompensated cirrhosis | 100 (20.7–100) | 100 (20.7–100) | NA | 100 (20.7–100) | NA | 100 (20.7–100) | 100 (67.6–100) | 100 (34.2–100) | 100 (56.6–100) | 100 (20.7–100) |
Treatment-naive | 100 (75.8–100) | 100 (67.6–100) | 100 (51.0–100) | 83.3 (43.6–97.0) | NA | 83.3 (43.6–97.0) | 99.1 (94.8–99.8) | 100 (88.6–100) | 98.6 (92.3–99.7) | 100 (61.0–100) |
Treatment-experienced | 100 (34.2–100) | 100 (34.2–100) | NA | 100 (56.6–100) | 100 (20.7–100) | 100 (51.0–100) | 91.3 (79.7–96.6) | 83.3 (43.6–97.0) | 92.3 (79.7–97.3) | 100 (20.7–100) |