Table 1.
Frequency of clinical diagnostic subgroups in patients with childhood-onset ESKD versus adult-onset ESKD
| Diagnostic group | Childhood-onset ESKDa |
Adult-onset ESKDb |
||
|---|---|---|---|---|
| N | % | N | % | |
| CAKUT | (39) | NR | ||
| Aplasia/hypoplasia/dysplasia | 1769 | 16 | ||
| Obstructive uropathy | 1713 | 15 | ||
| Reflux nephropathy | 576 | 5 | ||
| Prune belly | 279 | 2 | ||
| Glomerulonephritis | 1845 | 16 | 8802 | 8 |
| FSGS | 1308 | 12 | – | |
| Congenital nephrotic syndrome | 289 | 3 | – | |
| Membranous nephropathy | 51 | <1 | – | |
| Cystic kidney disease | 2482 | 2 | ||
| PKD | 339 | 3 | ||
| Medullary cystic kidney disease | 305 | 3 | ||
| Cystinosis | 225 | 2 | NR | |
| Oxalosis | 58 | 1 | NR | |
| Renal infarct | 144 | 1 | NR | |
| Diabetic nephropathy | 11 | <1 | 51 339 | 44 |
| Hypertension | 0 | 0 | 33 585 | 29 |
| Other/unknown | 2270 | 20 | 20 782 | 18 |
| Total | 11 182 | 100 | 116 990 | 100 |
Note that where there is a much higher occurrence of CAKUT (39%) in childhood-onset disease, diabetic nephropathy (44%) and hypertensive nephropathy (29%) predominate in adult-onset disease.
Adapted from Contributions of the Transplant Registry: The 2014 Annual Report of the North American Pediatric Renal Trials and Collaborative Studies, https://web.emmes.com/study/ped/annlrept/annualrept2014.pdf (8 February 2019, date last accessed).
Adapted from the 2015 United States Renal Data System Annual Data Report detailing the primary cause of ESRD in incident cases of hemodialysis, peritoneal dialysis and transplantation in the US population, https://www.usrds.org/2015/download/vol2_USRDS_ESRD_15.pdf (8 February 2019, date last accessed).
NR, not reported; PKD, polycystic kidney disease.