Table 2.

Functions of diverse beta-glucans and their application in cervical cancer

Beta-glucan	Model (In vitro, In vivo, Human)	Outcome (s)	Application in cervical cancer (Therapeutic / Prevention)	References
SPG	Human study	Promoting the recovery of T lymphocytes and natural killer cells	Treatment (adjuvant to radiotherapy)	[125]
SPG	Human study	Increasing the survival and recurrence time	Treatment (adjuvant to immunotherapy)	[126]
SPG	Human study	stimulating a rapid recovery of the immunologic parameters impaired by radiotherapy	Treatment (adjuvant to radiotherapy)	[127]
SPG	Human study	Increasing the survival and recurrence time	Treatment (in combination with irradiation therapy)	[128]
SPG	Human study	Increasing the number and secretion of TNF, IL-1 and IFN-gamma	Treatment	[129]
SPG	Human study	Augmentation helper T (Th) cell functions of pelvic lymph nodes	Treatment	[130, 131]
SPG	Human study	Increasing infiltration of Langerhans cells and improving local response to radiation treatment	Treatment	[132]
SPG	Human study	Augmentation of lymphocyte infiltration	Treatment	[133]
SPG	Human study	Augmentation of lymphocyte and Langerhans cell infiltration	Treatment	[134]
Curdlan	In vitro	More cytotoxicity and a broader distribution of loaded drug	Treatment (as drug carrier for epirubicin)	[135]
LBE	In vitro	Anti-cancer effects	Treatment	[136]
SCG	In vivo	Enhancing the hematopoietic response, recovering leukocyte population in peritoneal cavity	Treatment	[137]
PG101	In vivo	Induces the differentiation of progenitor cells to granulocytes and/or proliferation of the committed cells	Treatment	[138]
Zymosan	In vivo	Induction in the activity of peritoneal macrophages	Treatment	[139]
PBG	In vitro	Affects on both humoral and cellular immune response by increasing the cytotoxic and helper T cells and the release of IFN-γ	Treatment and prevention	[140]
Lentinan	–	Increasing drug efficacy	Treatment (combined with cisplatin and docetaxel)	[141]