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VGLUT1 transport glutamate (Glu) mechanism diagram. VGLUT1 use proton electrochemical gradient generated by vascular ATPase to carry the glutamata anion (Glu) into the interior of synaptic vesicles. The outflow of chloride ions in synaptic vesicles increases the transport efficiency of VGLUT1. Another explanation is that VGLUT1 transports chloride ions out and transfers equal amounts of Glu. In summary, VGLUT1 acts as a transporter through two pathways
