Table 4.

GRADE

				Univariable			Multivariate			GRADE Factors
Prognostic Factor	# of studies	No. of participants	Phase of Investigation	+	0	–	+	0	–	Risk of Bias	Inconsistency	Indirectness	Imprecision	Moderate/Large effect size	Dose Effect	Overall Quality
Age	5	6585	3	4	0	0	4	0	0	Moderate	✘	✘	✘	✔	✔	++++
Impaired Physical Functiona	4	5530	3	3	0	0	4	0	0	Moderate	✘	✘	✘	✔	✔	++++
ADL disabilities	3	1724	3	3	0	0	3	0	0	Moderate	✘	✘	✘	✔	✔	++++
Frailty b	2	1545	3	1	0	0	2	0	0	Moderate	✘	✘	✘	✔	✔	++++
Stroke	2	4794	3	3	0	0	1	0	0	Moderate	✘	✔	✘	✔	✔	+++
Supportive environment prior to admission	2	4258	3	2	0	0	2	0	0	Moderate	✘	✔	✘	✔	✘	+++
IADL disabilities	2	1234	3	2	0	0	2	0	0	Moderate	✘	✘	✘	✔	✘	+++
Cognitive impairmentc	4	6198	3	3	0	0	1	0	0	Moderate	✘	✔	✘	✘	✔	++
Marital status (Married) vs Other	3	5181	3	0	0	3	0	0	2	Moderate	✘	✘	✘	✘	✔	++
Heart Failure	2	4794	2	2	0	0	0	0	0	Moderate	✘	✘	✘	✘	✘	++
Metastatic Cancer	2	4794	2	2	0	0	1	0	0	Moderate	✘	✘	✘	✔	✘	++
Lives with informal care giver	2	736	3	0	0	2	0	0	1	Moderate	✘	✘	✘	✘	✘	++
Sex (Female)	4	5633	3	1	3	0	1	1	0	Moderate	✔	✘	✘	✘	✘	+
Heart Valve Disease	2	4296	3	2	0	0	0	0	0	High	✘	✘	✘	✘	✘	+
Comorbidities Increasing number	4	2111	3	3	1	0	0	1	0	Moderate	✔	✘	✔	✘	✘	+

^aPhysical function as measured by mobility, gait, ability to transfer or physical function scores

^bMeasured using Rockwood frailty scale, Braden risk and Morse fall risk

^cCognitive impairment defined as low mini-mental state score, severe cognitive impairment, dementia or cognitive stage