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. 2020 Mar 4;21:243. doi: 10.1186/s13063-020-4150-5

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Pragmatic Explanatory Continuum Indicator Summary (PRECIS-2) wheel for aspects of the pragmatic trial. The investigators have quantified each of the nine PRECIS-2 domains along the “explanatory–pragmatic continuum”, where 1 = most explanatory and 5 = most pragmatic. Generally, pragmatic trials correspond with “real-world effectiveness trials” and explanatory trials correspond with “efficacy/mechanistic trials”