Table 4.

Bone parameters (fracture, BMD and TBS) according to quartiles of interleukin 6

	First	Second	Third	Fourth	P-valuea	P-value trend testb	P-value adjustedc
N	333	330	326	329
Interleukin 6, median [IQR]	0.41 [0.22–0.63]	1.52 [1.19–1.87]	3.84 [2.98–5.30]	22.01 [12.33–61.31]
Traumatic fracture (%)	76 (22.8)	99 (30.0)	80 (24.5)	91 (27.6)	0.155		0.497
Major osteoporotic fracture (%)	32 (9.61)	39 (11.82)	36 (11.04)	35 (10.64)	0.832		0.997
Incident fracture 5 years	20/323 (6.2)	12/320 (3.7)	21/318 (6.6)	22/323 (6.8)	0.320		0.461
Spine average BMD	0.921 ± 0.168	0.932 ± 0.164	0.933 ± 0.155	0.915 ± 0.168	0.437	0.696	0.375
Spine average T-score	−1.13 ± 1.59	−1.03 ± 1.54	−1.01 ± 1.46	−1.18 ± 1.58	0.424	0.707	0.367
Spine average TBS	1.322 ± 0.104	1.326 ± .0105	1.319 ± 0.103	1.319 ± 0.098	0.773	0.509	0.525
Femoral neck BMD	0.724 ± 0.113	0.727 ± 0.114	0.741 ± 0.112	0.727 ± 0.199	0.234	0.424	0.391
Femoral neck T-score	−1.13 ± 1.01	−1.096 ± 1.02	−0.97 ± 1.00	−1.10 ± 1.07	0.223	0.397	0.361
Femur total BMD	0.848 ± 0.118	0.857 ± 0.121	0.869 ± 0.119	0.845 ± 0.112	0.046	0.945	0.979
Femur total T-score	−0.77 ± 0.96	−0.69 ± 0.98	− 0.59 ± 0.97	−0.79 ± 0.92	0.043	0.913	0.987

Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variables^a, p of trend^b and after multiple adjustment^c (age, BMI, smoker, diabetes, alcohol, calcium, HRT)