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. 2020 Mar 4;13:9. doi: 10.1186/s13072-020-00335-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Localization of linker histone H1t in the mouse rDNA element. a Peak distribution of H1t across various regions of the rDNA element [43]. Distribution of H1t peaks with respect to SINE elements (green dotted lines) localized in the rDNA element. The red lines demarcate various regions of the rDNA element, blue lines are the H1t peaks, and the various regions of the rDNA element have been labeled below the peak distribution maps. Density plot of H1t peaks overlapping with methylated CpGs (SRS557654) in b. rDNA and c extranucleolar genomic regions. The y-axis represents the density function and the x-axis represents the bandwidth parameter. N represents the number of observations. The red lines demarcate various regions of the rDNA element [43], blue lines are the H1t peaks, and the various regions of the rDNA element have been labeled below the peak distribution maps. d Level of DNA methylation in the extranucleolar, nucleolar and the total H1t peaks. The data have been plotted in terms of the number of methylated cytosines as mean ± SD