Table 3.

Outcome of Fetal HCMV Infections at Birth After Prenatal Testing Performed at 20–21 Weeks’ Gestation

Amniotic Fluid qPCR	Ultrasound Findings	Outcome at Birth
Negative	Negative	No congenital infection (~95% of cases) Congenital infection without long-term neurological sequela (~5% of cases)
Low viral load	Negative	High probability of asymptomatic congenital infection
High viral load	Severe brain abnormalities	Symptomatic congenital infection
High viral load	Negative	Congenital infection; additional assessments are needed to refine the prognosis

Abbreviations: HCMV, human cytomegalovirus; qPCR, quantitative polymerase chain reaction.