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. 2020 Feb 13;21(4):1761–1770. doi: 10.3892/mmr.2020.10987

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Knockdown of MALAT1 increases lipid accumulation and the levels of T-CHO in ox-LDL-stimulated macrophages. Differentiated macrophages were transfected with NC siRNA or MALAT1 siRNA. At 24 h after transfection, cells were stimulated with 50 mg/ml ox-LDL for 48 h. (A) Representative images of Oil Red O staining. Scale bar, 50 µm. (B) Levels of T-CHO in macrophages. Data are presented as the mean ± SD. *P<0.05 vs. control group. ^&&P<0.01 vs. ox-LDL + NC siRNA group. NC, negative control; siRNA, small interfering RNA; ox-LDL, oxidized low-density lipoprotein; MALAT1, metastasis associated lung adenocarcinoma transcript 1; T-CHO, total cholesterol.